Muscle Physiology Laboratory (Dodd)

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Our research is focused on understanding how skeletal muscle adapts to conditions of reduced use. Our primary interest is the study of the protein degradation pathways involved in muscle remodeling and possible countermeasures that may be employed. Most recently we have studied heat shock proteins and their role as a countermeasure in muscle wasting and the signaling pathways involved in this process. In addition, we are studying the exaggerated muscle wasting seen in conditions that result in denervation of muscle such as nerve damage and botulinum neurotoxin poisoning.

PI: Stephen Dodd, Ph.D.

Research Interests:

  • The study of muscle dysfunction and adaptation associated with disuse
  • The effects of botulinum neurotoxin on muscle function and adaptation
  • The role of heat shock proteins in maintaining muscle mass during disuse